Incidence of Alzheimer Disease in a Biracial Urban Community
Open Access
- 1 February 2003
- journal article
- editorial
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 60 (2) , 185-189
- https://doi.org/10.1001/archneur.60.2.185
Abstract
LARGE-SCALE STUDIES of Alzheimer disease (AD) and the effects of the apolipoprotein E (APOE) ϵ4 allele on risk are uncommon among the black population in the United States.1-4 After its initial description,5 the finding that the APOE ϵ4 allele is associated with increased risk of AD has been replicated in many white populations,6,7 but studies1,8 of populations with a large fraction of American or African black subjects have usually suggested less effect of the APOE ϵ4 allele on disease risk. Therefore, we studied APOE and the risk of incident AD among black and white subjects in a geographically defined population.Keywords
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