The isolation of barium and calcium diketo-l-gulonates and the biological significance of 2:3-diketo-l-gulonic acid
- 1 January 1945
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 39 (1) , 1-4
- https://doi.org/10.1042/bj0390001b
Abstract
Ba and Ca salts of 2:3 diketo-l-gulonic acid from solns. of mutarotated dehydroascorbic acid have been isolated in 60 and 50% yields respectively and characterized. On a diet in which a daily dose of 0.5 mg. of l-ascorbic acid gave a high degree of protection against scurvey, the Ca salt showed no antiscorbutic activity for guinea pigs in daily doses equivalent to 0.5 mg. of 2:3 diketo-1-gulonic acid or in 20 mg. doses. The latter quantity upon reduction with H2S yielded an indophenol reducing compound corresponding to 0.5 mg. of 1-ascorbic acid. l-Ascorbic acid was regenerated from Ba diketogulonate by reduction with HI.This publication has 5 references indexed in Scilit:
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