Konbamide, a novel peptide with calmoduiin antagonistic activity from the Okinawan marine sponge Theonella sp.
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 15,p. 1050-1052
- https://doi.org/10.1039/c39910001050
Abstract
A novel peptide, konbamide 1, with calmodulin antagonistic activity has been isolated from the Okinawan marine sponge Theonella sp. and the structure elucidated to be a unique hexapeptide with an ureido bond on the basis of spectroscopic data, including two-dimensional NMR techniques and FAB MS–MS analysis (FAB = fast atom bombardment).Keywords
This publication has 18 references indexed in Scilit:
- Revised structures of prianosins C and D, antineoplastic alkaloids from the Okinawan marine sponge Prianos melanosTetrahedron Letters, 1991
- Iejimalides C and D, new antineoplastic 24-membered macrolide sulfates from the okinawan marine tunicate Eudistoma cf. rigidaTetrahedron Letters, 1991
- Stelliferins A–F, new antineoplastic isomalabaricane triterpenes from the Okinawan marine sponge Jaspis stellifera.Tetrahedron, 1991
- Bioactive marine metabolites. 33. Cyclotheonamides, potent thrombin inhibitors, from a marine sponge Theonella spJournal of the American Chemical Society, 1990
- Niphatesines A–D, new antineoplastic pyridine alkaloids from the okinawan marine sponge Niphates sp.Journal of the Chemical Society, Perkin Transactions 1, 1990
- Theonellamide F. A novel antifungal bicyclic peptide from a marine sponge Theonella spJournal of the American Chemical Society, 1989
- Structure of theonellapeptolide Ie, a new tridecapeptide lactone from an okinawan marine sponge, Theonella sp. (theonellidae).CHEMICAL & PHARMACEUTICAL BULLETIN, 1987
- Theonellamine B, a novel peptidal Na,K-atpase inhibitor, from an okinawam marine sponge of the genus Theonella.Tetrahedron Letters, 1986
- Structure of theonellapeptolide Id, a new bioactive peptolide from an Okinawan marine sponge, Theonella sp. (Theonelliae).CHEMICAL & PHARMACEUTICAL BULLETIN, 1986
- Reduction of Aryl Halides and N-Hydroxy Nitrogen Compounds in Fast Atom Bombardment Mass SpectrometryBulletin of the Chemical Society of Japan, 1985