CHEMOTHERAPY OF AN EXPERIMENTAL GLIOMA WITH NITROSOUREAS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 37  (2) , 476-481
Abstract
Chemotherapy experiments were performed with 2 nitrosourea drugs in an experimental mouse brain tumor model. Cell suspensions of a transplantable mouse ependymoblastoma were injected i.c. [intracerebrally] by a stereotactic frame. The drugs used were 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea and 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea and were given by i.p. or direct intraneoplastic (i.n.) injection on the 5th day after tumor cell implantation. Injections i.n. of drugs were made with the stereotactic frame. Both drugs were highly effective in increasing the median day of death and in yielding large numbers of long-term survivors. Effectiveness was evident after i.p. or i.n. injection. With certain dosage schedules such as every 2 h for 5 injections daily on 2 consecutive days, i.n. injection was more effective and less toxic than i.p. injection. The reason why repeated i.n. injections produced less toxicity than repeated i.p. injections is not definitely known but may be due to local metabolism of the drugs in the tumors and surrounding brain to a less toxic form. This is the 1st laboratory report of direct i.n. injection of the nitrosoureas, and these results are encouraging.

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