The regulation of cell migration by PTEN
- 1 December 2005
- journal article
- review article
- Published by Portland Press Ltd. in Biochemical Society Transactions
- Vol. 33 (6) , 1507-8
- https://doi.org/10.1042/bst20051507
Abstract
In vertebrates, the tumour suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 10) regulates many cellular processes through its PtdIns(3,4,5)P3 lipid phosphatase activity, antagonizing PI3K (phosphoinositide 3-kinase) signalling. Given the important role of PI3Ks in the regulation of directed cell migration and the role of PTEN as an inhibitor of migration, it is somewhat surprising that data now indicate that PTEN is able to regulate cell migration independent of its lipid phosphatase activity. Here, we discuss the role of PTEN in the regulation of cell migration.Keywords
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