Cerebral neurogenesis is induced by intranasal administration of growth factors

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Abstract
Neurogenesis persists in the adult brain, where it may contribute to repair and recovery after injury, but the lack of methods for noninvasive stimulation of cerebral neurogenesis limits its potential for clinical application. We report that intranasal administration of either fibroblast growth factor–2 or heparin‐binding epidermal growth factor–like growth factor increases neurogenesis, measured by the incorporation of bromodeoxyuridine into cells that express the early neuronal marker protein doublecortin in the subventricular zone of mouse brain. These findings indicate that intranasal growth factors may have potential as neurogenesis‐promoting therapeutic agents. Ann Neurol 2003;53:405–409