Studies on the inactivation of encephalitogenic myelin basic protein by serum
- 29 January 2009
- journal article
- research article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 60 (3) , 140-148
- https://doi.org/10.1111/j.1600-0404.1979.tb02961.x
Abstract
Previous reports that myelin basic protein loses its encephalitogenic activity when incubated in normal serum at 37.degree. C are confirmed. The mechanisms for this were studied. 125I-labeled human myelin basic protein was rapidly degraded by normal guinea pig serum to low MW products as shown by polyacrylamide gel electrophoresis. An intermediate product of MW about 6000 daltons was seen. Plasma had a much lower degradative activity than serum; the half-life of myelin basic protein was 3.8 h in plasma compared with 12 min in serum. Serum degraded myelin basic protein was no longer capable of suppressing experimental allergic encephalomyelitis in the guinea pig nor of eliciting delayed-type hypersensitivity in guinea pigs sensitized to myelin basic protein.Keywords
This publication has 16 references indexed in Scilit:
- PRECIPITATION OF MYELIN BASIC PROTEIN BY β-LIPOPROTEIN OF HUMAN SERUMActa Neurologica Scandinavica, 2009
- Relative Effectiveness of Spinal Cord and Purified Myelin Basic Protein in Producing Resistance to Experimental Allergic EncephalomyelitisEuropean Neurology, 1979
- Serum degradation of myelin basic protein with loss of encephalitogenic activity: Evidence for an enzymatic processCellular Immunology, 1978
- Myelin basic protein serum factor (MBP-SF) in adult lewis rats: A method for detection and evidence that MBP-SF influences the appearance of antibody to MBP in animals developing experimental allergic encephalomyelitisImmunochemistry, 1978
- THE ENCEPHALITOGENIC ACTIVITY AND MYELIN BASIC PROTEIN CONTENT OF ISOLATED OLIGODENDROGLIAJournal of Neurochemistry, 1977
- The onset and progression of the lesion in multiple sclerosisJournal of the Neurological Sciences, 1975
- Inhibition by serum of encephalitogenic activity of myelin basic protein: Nature of the serum factor responsibleCellular Immunology, 1975
- Inhibition by Serum of Encephalitogenic Activity of Myelin Basic ProteinInternational Archives of Allergy and Immunology, 1975
- Suppression by several synthetic polypeptides of experimental allergic encephalomyelitis induced in guinea pigs and rabbits with bovine and human basic encephalitogenEuropean Journal of Immunology, 1973
- ENCEPHALITOGEN‐INDUCED INHIBITION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS: PREVENTION, SUPPRESSION AND THERAPY*Annals of the New York Academy of Sciences, 1965