Protective effect of the hemopump left ventricular assist device in experimental cardiogenic shock

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Abstract
The efficacy of the new cable-driven rotating left ventricular assistdevice Hemopump in cardiogenic shock was examined in experiments with adultsheep (n = 14; body weight 50-71 kg). Shock was induced by high frequencyventricular pacing. Aortic, pulmonary, central venous and left ventricularpressures as well as electromagnetic measurements of coronary blood flowwere recorded continuously; cardiac output was measured by thermodilutiontechnique. Blood samples for determination of oxygen content, electrolytesand lactate were taken under control conditions, in shock, and during pumpintervention at different levels of pump speed. Vascular resistance, totalbody and myocardial oxygen consumption as well as myocardial uptake andrelease of lactate were calculated. High frequency pacing led to asignificant decrease in cardiac output (from 3.8 +/- 0.8 to 2.2 +/- 1.6l/min), mean aortic pressure (89.1 +/- 14.4 to 47.6 +/- 7.2 mmHg), andtotal body oxygen consumption (2.6 +/- 0.3 to 1.4 +/- 0.7 ml/min per kg),as well as myocardial release of lactate (arterial coronary-venousdifference of lactate: 0.27 +/- 0.26 to -0.32 +/- 0.72 mmol/l). Hemopumpassist in this condition resulted in a significant increase in cardiacoutput (to 2.8 +/- 0.6 l/min), mean aortic pressure (to 65.6 +/- 13.9mmHg), and myocardial perfusion pressure (from 25.5 +/- 11.0 to 59.0 +/-14.7), and led to nearly normal total body oxygen consumption (2.5 +/- 0.7ml/min per kg), a decrease in myocardial oxygen consumption (from 6.1 +/-2.1 in shock, to 4.8 +/- 1.7 ml/min per 100 g), and to normal arterialcoronary-venous difference of lactate (0.24 +/- 0.26 mmol/l).(ABSTRACTTRUNCATED AT 250 WORDS)

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