Differential Monocyte Activation Underlies Strain-SpecificMycobacterium tuberculosisPathogenesis
Open Access
- 1 September 2004
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (9) , 5511-5514
- https://doi.org/10.1128/iai.72.9.5511-5514.2004
Abstract
In vitro infection of monocytes with Mycobacterium tuberculosis HN878 and related W/Beijing isolates preferentially induced interleukin-4 (IL-4) and IL-13, which characterize Th2 polarized immunity. In contrast, CDC1551 induced more IL-12 and other molecules associated with phagocyte activation and Th1 protective immunity. The differential cytokine-chemokine response was mediated by extracted lipids, suggesting that these molecules regulate host responses to infection.Keywords
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