DRUGS AND BILIRUBIN

Publisher Website
Google Scholar
Abstract
Current concepts of the mechanisms of biotransformation and drug detoxification evolved largely as a result of studies of the last decade and a half.1 It was demonstrated that most of the enzyme systems responsible for the oxidative, reductive, hydrolytic, and conjugating reactions of drugs, toxins, and many endogenous substances are located in the endoplasmic reticulum of the liver cell, operationally defined as the microsomal fraction. Remmer2 and Conney and his collaborators3 were among the first to point out that many of the compounds metabolized by these pathways have the capacity of enhancing not only their own metabolic transformation, but also that of substances chemically or biologically unrelated to the stimulating agent.

This publication has 0 references indexed in Scilit: