An Efficient and Stereoselective Synthesis of (E)-α-Enones via Arsonium Salts. Preparation of Key Intermediates for the Synthesis of Brassinosteroid and Prostaglandin
- 1 January 1988
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1988 (12) , 975-977
- https://doi.org/10.1055/s-1988-27772
Abstract
(E)-1-Alkenyl alkyl ketones [(E)-α-Enones] are prepared in high yields and with high stereoselectivity by reaction of (2-oxoalkyl)triphenylarsonium bromides with aldehydes under solid-liquid phase-transfer conditions. Application of this methodology to the preparation of key intermediates for the synthesis of brassinosteroid and prostaglandin PGF2α is also reported.Keywords
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