Congenital Malformation among Infants of Epileptic Mothers treated during Pregnancy — The Report of a Collaborative Study Group in Japan

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Abstract
A multi-institutional collaborative study was conducted on the risk of congenital abnormalities among infants of pregnant epileptics. The 902 pregnancies collected by July, 1977, were divided into the treated group, the non-treated group and the unknown group. The malformation rates among live births of the first and the second groups were 11.5% and 2.3%, respectively; however, it was estimated that the rate would have been 6.75% among the treated group if trimethadione-treatment had been avoided. The effects of maternal background and antiepileptic treatment were analyzed fully in connection with the possibility of congenital malformation.

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