The tissue penetration, as measured by a blister technique, and pharmacokinetics of cefsulodin compared with carbenicillin and ticarcillin
- 1 June 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 7 (6) , 637-642
- https://doi.org/10.1093/jac/7.6.637
Abstract
Serum and cantharides-induced blister fluid levels of cefsulodin, carbenicillin and ticarcillin were compared in a semi-crossover study, after a I g intravenous bol us injection. The serum concentration/time curves for the three β-lactams were essentially similar, the half-lives being 1·25–1·5 h. Cefsulodin and ticarcillin penetrated into the fluid to a greater extent than carbenicillin. As cefsulodin is a more potent antibiotic against Pseudomonas aeruginosa it is suggested that this may be the agent of choice in treating infections caused by this pathogen.Keywords
This publication has 2 references indexed in Scilit:
- The Influence of Protein Binding upon Tissue Fluid Levels of Six -Lactam AntibioticsThe Journal of Infectious Diseases, 1980
- Cefsulodin, a cephalosporin with specific antipseudomonal activity; in vitro studies of the drug alone and in combinationJournal of Antimicrobial Chemotherapy, 1979