SPECTRUM OF PHARMACOLOGICAL ACTIONS ON BRAIN DOPAMINE - INDICATIONS FOR DEVELOPMENT OF NEW PSYCHOACTIVE-DRUGS - DISCUSSION OF AMANTADINES AS EXAMPLES OF NEW DRUGS WITH SPECIAL ACTIONS ON DOPAMINE SYSTEMS

Google Scholar
  • 1 January 1976
    • journal article
    • research article
    • Vol. 28  (6) , 551-556
Abstract
Amantadine (D1) and 1,3-dimethyl-5-aminoadamantane (D145), as examples of new drugs with special actions on dopamine systems, were discussed. D1 or D145 decreased significantly apomorphine or amphetamine induced stereotypy in rats, but in experiments with chronic pretreatment with amantadines, potentiation of stereotypy was observed. D145 (20 mg/kg) abolished stereotypy in these conditions. In biochemical experiments D1 or D145 were neither like apomorphine nor like amphetamine. D1 and D145 in addition to their amine releasing properties probably had the ability partially to occupy the dopaminergic receptor.

This publication has 1 reference indexed in Scilit: