Slow inactivation conserved in heteromultimeric voltage‐dependent K+ channels between Shaker (Kv1) and Shaw (Kv3) subfamilies
- 11 September 1995
- journal article
- Published by Wiley in FEBS Letters
- Vol. 371 (3) , 307-310
- https://doi.org/10.1016/0014-5793(95)00928-3
Abstract
Single K+ channels were recorded under the cell-attached mode in Xenopus oocytes injected with an equal amount of mRNAs coding for NGK1 (Kv1.2) and NGK2 (Kv3.1a) voltage-dependent K+ channels. A new class of channels of 20 pS in conductance with three degrees of inactivation was observed. The results suggest that voltage-dependent NGK1 Shaker and NGK2 Shaw K+ channels, from different subfamilies, assemble to form heteromultimeric K+ channels in Xenopus oocytes and show characteristics inherited from two parental channelsKeywords
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