C825T Polymorphism of the G Protein β 3 -Subunit and Antihypertensive Response to a Thiazide Diuretic
- 1 February 2001
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Hypertension
- Vol. 37 (2) , 739-743
- https://doi.org/10.1161/01.hyp.37.2.739
Abstract
The T allele of the C825T polymorphism of the gene encoding the β 3 -subunit of G proteins has been associated with increased sodium-hydrogen exchange and low renin in patients with essential hypertension. To assess its association with blood pressure response to diuretic therapy, we measured the C825T polymorphism in 197 blacks (134 men, 63 women) and 190 non-Hispanic whites (76 men, 114 women) with essential hypertension (mean±SD age 48±7 years), who underwent monotherapy with hydrochlorothiazide for 4 weeks. Mean declines in systolic and diastolic blood pressures were 6±2 ( P P 3 -subunit may help identify patients with essential hypertension who are more responsive to diuretic therapy.Keywords
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