In Vivo Studies On the Mechanism of Di(2-Ethylhexyl)Phthalate Carcinogenesis
- 1 April 1987
- journal article
- review article
- Published by SAGE Publications in Toxicology and Industrial Health
- Vol. 3 (2) , 151-163
- https://doi.org/10.1177/074823378700300211
Abstract
In a study sponsored by the National Toxicology Program, di(2-ethylhexyl)phthalate (DEHP) fed in the diet at 1.2% significantly increased the incidence of female rats with hepatocellular carcinomas. Extensive evaluation of DEHP for carcinogenicity has yielded negative results. The present investigations were designed to elucidate the mechanism of DEHP hepatocarcinogenesis under the conditions of the original bioassay.Keywords
This publication has 25 references indexed in Scilit:
- Di(2-ethythexyl)phthalate: lack of initiating activity in the liver of female F-344 ratsCarcinogenesis: Integrative Cancer Research, 1987
- Concentration-dependent inhibition of development of GGT positive foci in rat liver by the environmental contaminant di(2-ethylhexyl) phthalate.Environmental Health Perspectives, 1985
- Comparison of the short-term effects of di(2-ethylhexyl) phthalate, di(n-hexyl) phthalate, and di(n-octyl) phthalate in ratsToxicology and Applied Pharmacology, 1985
- Inhibition of phenobarbital and dietary choline deficiency promoted preneoplastic lesions in rat liver by environmental contaminant di(2-ethylhexyl)phthalateCancer Letters, 1984
- Lack of genotoxic activity of di(2-ethylhexyl)phthalate (DEHP) in rat and human hepatocytesCarcinogenesis: Integrative Cancer Research, 1984
- Inhibition of development of preneoplastic lesions in the livers of rats fed a weakly carcinogenic environmental contaminantCancer Letters, 1983
- The carcinogenicity of dietary di(2‐ethylhexyl) phthalate (DEHP) in fischer 344 rats and B6C3F1miceJournal of Toxicology and Environmental Health, 1982
- Hypolipidemics Carcinogenicity and Extrapolation of Experimental Results for Human Safety AssessmentsToxicologic Pathology, 1982
- Effects of various concentrations of ethyl-α-p-chlorophenoxyisobutyrate (clofibrate) on diethylnitrosamine-induced hepatic tumorigenesis in the ratCarcinogenesis: Integrative Cancer Research, 1982
- Initiation of chemical carcinogenesis requires cell proliferationNature, 1978