Chemically Induced Porphyria: Increased Microsomal Heme Turnover after Treatment with Allylisopropylacetamide
- 8 January 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 171 (3966) , 64-66
- https://doi.org/10.1126/science.171.3966.64
Abstract
Excessive induction of δ-aminolevulinic acid synthetase in rats after treatment with porphyria-inducing chemicals, such as allylisopropylacetamide, is accompanied by a decrease in microsomal heme and cytochrome P450 concentrations. Measurement of the radioactive decay after labeling of the heme moiety of submicrosomal particles shows increased breakdown of heme in rats treated with allylisopropylacetamide. The effects of allylisopropylacetamide on heme synthesis and heme turnover may be interrelatedKeywords
This publication has 17 references indexed in Scilit:
- Lipid oxidation in biological membranesArchives of Biochemistry and Biophysics, 1970
- Rapid loss of cytochrome P‐450 and haem caused in the liver microsomes by the porphyrogenic agent 2‐allyl‐2‐isopropylacetamideFEBS Letters, 1970
- Effect of 1,4-dihydro-3,5-dicarbethoxycollidine on hepatic microsomal haem, cytochrome b5 and cytochrome P450 in rabbits and miceBiochimica et Biophysica Acta (BBA) - General Subjects, 1969
- Behavior of hepatic microsomal cytochromes after treatment of mice with drugs known to disturb porphyrin metabolism in liverBiochemical Pharmacology, 1968
- Observations on the Decomposition of Hemin by Fatty Acid Hydroperoxides.Experimental Biology and Medicine, 1966
- Coordinate Synthesis of Heme and Apoenzyme in the Formation of Tryptophan PyrrolaseScience, 1966
- Increase in Activity of δ-Aminolevulinic Acid Synthetase in Liver Mitochondria Induced by Feeding of 3, 5-Dicarbethoxy-1, 4-dihydrocollidineJournal of Biological Chemistry, 1963
- The Kinetics of Catalase Synthesis and Destruction in VivoJournal of Biological Chemistry, 1962
- Experimental hepatic porphyria caused by feeding 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine. Comparison with sedormid porphyriaBiochemical Journal, 1962
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951