A weak association between TH and DRD2 genes and bipolar affective disorder in a Spanish sample.
Open Access
- 1 February 1995
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 32 (2) , 131-134
- https://doi.org/10.1136/jmg.32.2.131
Abstract
Genetic factors play an important role in the aetiology of bipolar affective disorder (BP). So far, results of linkage studies have been largely disappointing. We have searched for a possible association between polymorphic DNA markers of two candidate genes (tyrosine hydroxylase, TH; dopamine D2 receptor gene, DRD2) and BP in a population from central Spain. Our results are consistent with the existence of a weak association between these two genes and BP, in such a way that TH and DRD2 could be considered as minor genes contributing to susceptibility.Keywords
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