A Simple Gas Chromatographic Method for the Measurement of Dichloroacetic Acid in Plasma or Urine
- 1 January 1978
- journal article
- research article
- Published by Taylor & Francis in Analytical Letters
- Vol. 11 (11) , 953-966
- https://doi.org/10.1080/00032717808059747
Abstract
A method was developed for measurement of dichloracetic acid in plasma [human] or urine. The procedure is based on derivatization of dicloroacetic acid with methanol-boron trifluoride, extraction of the resulting methyl ester and gas chromatography. The method has good accuracy and precision, and can be used to determine concentrations as low as 0.04 .mu.g/ml.This publication has 3 references indexed in Scilit:
- Metabolic Effects of Dichloroacetate in Patients with Diabetes Mellitus and HyperlipoproteinemiaNew England Journal of Medicine, 1978
- Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acidsBiochemical Journal, 1974
- Gas chromatographic determination of dichloroacetic acid in plasma and urine using electron capture detectionBiochemical Medicine, 1973