The Oxidative Metabolism of α-Chlorohydrin in the Male Rat and the Formation of Spermatocoeles
- 1 January 1978
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 8 (9) , 573-582
- https://doi.org/10.3109/00498257809061257
Abstract
1. The oxidative metabolism of [3-36Cl]chloropropan-1,2-diol (α-chloro-hydrin, I) was studied in male rats. Two metabolites were isolated and identified as β-chlorolactic acid (IV) and oxalic acid (V). 2. Neither α-chlorohydrin nor β-chlorolactate was concentrated in any tissue. Traces of an intermediate metabolite, β-chlorolactaldehyde (III) were detected in the urine within 4 h of administration. Studies in vitro indicated that the metabolic pathway is: α-chlorohydrin, β-chlorolactaldehyde, β-chlorolactic acid. 3. A comparative study of the metabolism of 36Cl- and 14C-β-chlorolactate showed that oxalate was produced slowly and, as calcium oxalate, caused a type of renal glomerular nephritis. This pathological condition is responsible for the diuretic action of both α-chlorohydrin and β-chlorolactate and, in higher doses, for their toxicities. 4. The role of oxalate, as a metabolite of α-chlorohydrin and of a number of related compounds, in inducing the formation of spermatocoeles in the male rat reproductive tract is discussed.This publication has 34 references indexed in Scilit:
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