Genetic analysis of theT-H-2 region in non-t Chromosomes
- 1 January 1983
- journal article
- research article
- Published by Springer Nature in Immunogenetics
- Vol. 17 (5) , 445-455
- https://doi.org/10.1007/bf00696868
Abstract
A general breeding protocol useful in the construction of congenic lines of mice disparate in the 15 cMT-H-2 region of chromosome 17 in non-t chromosomes is described. Two such congenic lines, B6.TC2/Rn and B6.TC3/Rn, were derived from the C57BL/6J and B6.C-H-2 d/By strains using this protocol. Both B6.TC2 and B6.TC3 dissociate the quantitative activity locus for glyoxalase I (Qglo-1) from theH-2 complex, and hence possess BALB/cBy DNA centromeric toH-2. However, neither new strain is able to map anyH-2-associated restriction fragment length polymorphism with anH-2 cDNA probe even though both strains are recombinant in the 2 cMQglo-1-H-2K interval.This publication has 33 references indexed in Scilit:
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