Release of Slow-Reacting Substance of Anaphylaxis in the Rat: Polymorphonuclear Leukocyte

Abstract
The antigen-induced release of slow-reacting substance of anaphylaxis was studied in rats previously treated with different biological and pharmacological agents to deplete these animals of specific cellular elements. The polymorphonuclear leukocyte appears necessary as a crucial cell type for optimum release of the slow-reacting substance of anaphylaxis, whereas the mast cell and lymphocyte are not required.