Fusarium Infection with Unusual Skin Lesions in a Patient with Acute Lymphocytic Leukemia

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Abstract
A 27-year-old woman with acute lymphocytic leukemia developed red painful skin lesions, asymmetrically distributed over the face and extremities. They gradually increased in size and number, and in the center of each lesion blisters appeared followed by central necrosis with surrounding erythema. In several lesions the central necrosis was covered with a white powder shown to be fungal mycelium. Cultures from skin lesions and blood showed a Fusarium species. The skin lesions are helpful in recognizing this deep fungal infection in an immunocompromised host.

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