Studies on Diphenyl Ether Derivatives. II. : Synthesis and Pharmacological Actions of 2-Dialkylaminoalkoxydiphenyl Ether Derivatives.(2)

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Abstract
In continuation of the previous report on (Ia), its 2'-methyl (Ib) and 4'-chloro (Ic) derivatives were synthesized (Table I) and submitted to pharmacological screening. As shown in Table II, toxicity of Ib was greater than that of Ia while Ic had less toxicity. In general, introduction of a methyl or chlorine atom resulted in the increase of central depressive properties and other pharmacological actions remained the same as those of Ia or slightly weaker. The pressor action noted in the preceding report was weaker in all the compounds synthesized in the present series ecxept in No. 39.

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