Studies on Isothiazoles. I. 3-Arylisothiazole-4-carboxylic Acids
- 1 January 1968
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 16 (1) , 148-159
- https://doi.org/10.1248/cpb.16.148
Abstract
Preparations of 5-methyl-3-phenylisothiazole-4-carboxylic acid (Xa) and related compounds are described. 3-(Halogen-substituted phenyl)-5-methylisothiazole-4-carboxylic acids were also obtained by halogenation of 4-cyano-5-methyl-3-phenylisothiazole (VIIa), followed by hydrolysis. 5-Bromo-3-phenylisothiazole-4-carboxylic acid (XV) was prepared, and converted into the 5-methylthio derivative (XVI) which was oxidized to the corresponding sulfoxide (XVII) and sulfone (XVIII).Keywords
This publication has 0 references indexed in Scilit: