Comparative mutagenicity of dimethylaminoazobenzene and analogues in Salmonella
- 1 January 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 3 (5) , 559-561
- https://doi.org/10.1093/carcin/3.5.559
Abstract
The mutagen and hepatocarcinogen 4-dimethylaminoazobenzene (DAB) and 3 of its structural analogs, N-methyl-5-phenylazoindoline, 4-N-pyrrolidinylazobenzene and 4''-ethyl-4-N-pyrrolidinylazobenzene were tested for mutagenicity in S. typhimurium TA1538. DAB was used as a standard and an S-9 mix containing 30% Aroclor-induced rat liver S-9 produced more mutagenic product than did an S-9 mix containing the standard 10% S-9. All chemicals tested were mutagenic and required S-9. Both pyrrolidine analogs produced similar responses to DAB, while the indoline was only weakly mutagenic.This publication has 5 references indexed in Scilit:
- ACETYLORNITHINASE OF ESCHERICHIA COLI: PARTIAL PURIFICATION AND SOME PROPERTIESPublished by Elsevier ,2021
- A rapid and simple scheme for confirmation of salmonella tester strain phenotypeEnvironmental Mutagenesis, 1981
- Comparative carcinogenicities of 4-N-pyrrolidinylazo-benzene, its 4′-ethyl derivative, N-methyl-5-phenylazoindoline, and N,N-dimethyl-4-aminoazobenzene in the ratCarcinogenesis: Integrative Cancer Research, 1980
- Studies in vitro to discern the structural requirements for carcinogenicity in analogues of the carcinogen 4-dimethylaminoazobenzene (butter yellow)Carcinogenesis: Integrative Cancer Research, 1980
- In vitro evaluation of some derivatives of the carcinogen butter yellow: implications for environmental screeningBritish Journal of Cancer, 1978