Hepatic and intestinal metabolism of indinavir, an HIV protease inhibitor, in rat and human microsomes: Major role of CYP3A
- 25 April 1997
- journal article
- Published by Elsevier in Biochemical Pharmacology
- Vol. 53 (8) , 1187-1195
- https://doi.org/10.1016/s0006-2952(97)00100-7
Abstract
No abstract availableKeywords
This publication has 10 references indexed in Scilit:
- Utility of in vitro drug metabolism data in predicting in vivo metabolic clearanceBiochemical Pharmacology, 1994
- Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme inductionClinical Pharmacology & Therapeutics, 1992
- Heterogeneity of cytochrome P450IIIA expression in rat gut epitheliaGastroenterology, 1992
- Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymesChemical Research in Toxicology, 1991
- Cytochrome P450 of small intestinal epithelial cellsGastroenterology, 1985
- Physiologically Based Pharmacokinetic Modeling: Principles and ApplicationsJournal of Pharmaceutical Sciences, 1983
- Time and dose dependence of 3-methylcholanthrene-induced metabolism in rat intestinal mucosal cells and microsomesBiochemical Pharmacology, 1982
- Prediction of intestinal first-pass effect of phenacetin in the rat from enzyme kinetic data — correlation with in in vivo data using mucosal blood flowBiochemical Pharmacology, 1982
- Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance: Extrapolation of data to benzodiazepines and phenytoinJournal of Pharmacokinetics and Biopharmaceutics, 1980
- Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearanceJournal of Pharmacokinetics and Biopharmaceutics, 1977