The Effect of Histamine, H1and H2Agonists, and H1and H2Antagonists on Postprandial Pancreatic Polypeptide Release in Dogs

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Abstract
The influence of histamine, H1 and H2 agonists (2-AETD and dimaprit), and H1 and H2 antagonists (mepyramine and Cimetidine) on the postprandial release of pancreatic polypeptide (PP) was assessed in five Labrador retrievers. Infusions of histamine, 0.25 μmol kg−1h−1; 2AETD, 4 μmol kg−1h−1; and dimaprit, 1 μmol kg−1h−1, enhanced postprandial release (131-189% of control values). The response to 2-AETD and dimaprit was significantly different from control values (p < 0.05). An increase was observed even when 50 mg mepyramine and 400 mg Cimetidine were injected as intravenous boluses (131-139% of control values (p < 0.05)). The action of the antagonists may be explained by partial agonism or histamine release induced by these agents. It is concluded that postprandial PP release is stimulated by H1 and H2 receptors.