Separation and identification of methotrexate and its metabolites, 7-hydroxymethotrexate and polyglutamates, in human tissues by reversed-phase high-performance liquid chromatography coupled with radioimmunoassay
- 1 January 1987
- journal article
- research article
- Published by Elsevier in Journal of Chromatography B: Biomedical Sciences and Applications
- Vol. 415 (2) , 445-449
- https://doi.org/10.1016/s0378-4347(00)83241-7
Abstract
No abstract availableThis publication has 9 references indexed in Scilit:
- Polyglutamation of methotrexate. Is methotrexate a prodrug?Journal of Clinical Investigation, 1985
- Detection by high-performance liquid chromatography of methotrexate and its metabolites in tumor tissue from osteosarcoma patients treated with high-dose methotrexate/leucovorin rescueBiochemical Pharmacology, 1984
- Methotrexate and methotrexate polyglutamates in human sarcoma metastases after high-dose methotrexate therapyJournal of Molecular Medicine, 1983
- Formation and disposition of 7-hydroxymethorexate in rabbitsBiochemical Pharmacology, 1983
- Rapid formation of poly-gamma-glutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cell in vitro.Journal of Biological Chemistry, 1982
- High-pressure liquid chromatography analysis of methotrexate polyglutamates in cultured human breast cancer cellsBiochemical Pharmacology, 1981
- Plasma methotrexate as determined by liquid chromatography, enzyme-inhibition assay, and radioimmunoassay after high-dose infusion.Clinical Chemistry, 1980
- Degradation and clearance of methotrexate in children with osteosarcoma receiving high-dose infusionMedical and Pediatric Oncology, 1978
- Carrier-mediated Transport of the Folic Acid Analogue, Methotrexate, in the L1210 Leukemia CellJournal of Biological Chemistry, 1968