Synthesis of N-t-Boc-4-S-t-Butyl-L-thiophenylalanineviaPalladium Catalyzed Cross-Coupling Reaction of N-t-Boc-4-Iodo-L-phenylalanine witht-Butylthiol or Sodiumt-Butylthiolate

Abstract
Cross-coupling reaction of N-t-Boc-4-iodo-L-phenylalanine with t-BuSH proceeded efficiently in the presence of Pd2dba3.CHCl3/DPPF as the catalyst system. However, Pd2dba3.CHCl3/DPPB was found to be more effective for coupling with t-BuSNa.