THE INFLUENCE OF HYPOTHALAMIC STIMULATION ON INTESTINAL ACTIVITY

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Abstract
Expts. employing original modifications of the Horsley-Clarke technique in 14 cats indicate that stimulation of the ant. portion of the hypothalamus with faradic currents too weak to induce typical emotional mimetic responses causes segmentation, peristalsis and pendular movements of the small intestine in both anesthetized and recovery preps. Inhibition of intestinal activity is induced by strong electrical stimulation of any portion of the hypothalamus, the degree of intestinal inhibition corresponding to the intensity of the emotional mimetic responses concurrently elicited. The inj. of from 0.07 to 0.08 mgm. per kgm. of strychnine sulphate into the diencephalon induces slight and variable intestinal effects, but the inj. of larger amts. of the drug is consistently followed by spasticity, blanching and diminished motility of the gut. Electrical stimulation of the hypothalamus after its inj. with strychnine reveals inconsistently lowered thresholds for the diencephalic enteromotor reactions.

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