The Embryology of Vertebrate Pigment Cells. Part I. Amphibia

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Abstract
The history of the neural crest theory of pigment cell origin in vertebrates is traced. Modern exptl. methods of excision and grafting yield data which support this theory and establish it conclusively for amphibia. A hypothesis is suggested that the prospective pigment cells have different thresholds of reaction to the melanogenic substances. The nature of the melanogenic substance present in the ectoderm and mesoderm of amphibia embryos is not known; it may be either an oxidase or a chromogen precursor.