Blood glucose lowering sulfonamides with asymmetric carbon atoms. 3. Related N-substituted carbamoylbenzoic acids

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Abstract
Both enantiomers of 4-N-[1-(5-fluoro-2-methoxyphenyl)ethyl]carbamoylmethylbenzoic acid display hypoglycemic activity. The more potent (S) enantiomer is approximately equipotent with the acylaminoethylbenzoic acids of the type HB 699 [4-[2-(5-chloro-2-methoxybenzamido)-ethyl]benzoic acid]. Apparently these benzoic acids act at the same receptor as the hypoglycemic sulfonylureas and sulfonylaminopyrimidines and the receptor includes important binding sites.

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