Halothane Uptake in Man at Constant Alveolar Concentration

Open Access
Publisher Website
Google Scholar
Abstract
Uptake of halothane at a constant alveolar concentration was determined in 10 healthy human beings. Uptake was high at first and rapidly decreased during the first 20 minutes. At 0.8% alveolar concentration uptake was 81 ml/minute at 1 minute, 47 ml at 5 minutes, 34 ml at 10 minutes, and 28 ml at 20 minutes. Uptake decreased slowly thereafter until at 160 minutes it was 12 ml/minute. This rate of uptake paralleled that predicted mathematically using a 4 compartment model of the body. The appreciable and constantly diminishing uptake was shown to have the following implications anesthetic level may not be related rigidly to inflowing concentration in an anesthetic system: instead anesthetic level must be appreciated as being the result of numerous factors including inflow rate and concentration, ventilation, and uptake.
Keywords

This publication has 1 reference indexed in Scilit: