The structure of inducing factors for virginiamycin production in Streptomyces virginiae.
- 1 January 1987
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 40 (4) , 496-504
- https://doi.org/10.7164/antibiotics.40.496
Abstract
Virginiamycin inducing factors (including material or inducing factor) of Streptomyces virginiae were isolated from the culture borth of this microbe and separated into three closely related compounds. They were named virginiae butanolides A, B and C and their structures were determined as 2-(1''-hydroxy-5''-methylhexyl)-3-(hydroxymethyl)butanolide (6), 2-(1''-hydroxy-4''-methylhexyl)-3-(hydroxymethyl)butanolide (7) and 2-(1''-hydroxyhexyl)-3-(hydroxymethyl)butanolide (8), respectively. Part of their stereochemistry was also determined. Racemic virginiae butanolide C was synthesized to confirm their structures.This publication has 3 references indexed in Scilit:
- B-factor, an essential regulatory substance inducing the production of rifamycin in a Nocardia sp.The Journal of Antibiotics, 1984
- Interspecific inducers of cytodifferentiation and anthracycline biosynthesis from Streptomyces bikinensis and S. cyaneofuscatusBiotechnology Letters, 1983
- Revision of the absolute configuration of a-factorTetrahedron, 1983