Coordination of Urosonography and Prostate-Specific Antigen in the Diagnosis of Nonpalpable Prostate Cancer

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Abstract
When first detected, prostate cancer has usually spread beyond the confines of the gland. Heretofore, nonpalpable prostate cancer has been found only by incidental discovery at the time of prostatectomy for presumably benign obstructive disease or after the development by patients of manifestations of advanced disease. By utilizing prostate urosonography and serum prostate-specific antigen, we have been able to discover prostate cancer in 5.2% of 1035 men between the ages of 50 and 89 whose prostates did not suggest the disease on digital rectal examination.