Beyond Simple Pooling for HIV Screening
- 1 December 1992
- journal article
- research article
- Published by Taylor & Francis in Journal of Immunoassay
- Vol. 13 (4) , 545-557
- https://doi.org/10.1080/15321819208019835
Abstract
We discuss some theoretical features underlying the successful uses of pooling in testing HIV seroprevalence. In particular it is shown that there is a scaling relation for the distribution of positive sera among the pools. A multi-stage pooling method consisting of repeatedly halving the positive pools is proposed. Concentrating on the number of tests required for screening all positive individuals the method is shown to be highly efficient in low prevalence situations.Keywords
This publication has 6 references indexed in Scilit:
- HIV-1, hepatitis (A,B, and C), and measles in Romanian childrenThe Lancet, 1990
- Seroprevalence and clinical manifestations of HIV-1 infection in Kananga, ZaireAIDS, 1990
- Prevalence of HIV-1 infection in the Kagera region of TanzaniaAIDS, 1990
- Successful use of pooled sera to determine HIV-1 seroprevalence in Zaire with development of cost-efficiency modelsAIDS, 1990
- DNA amplification of HIV-1 in seropositive individuals and in seronegative at-risk individualsAIDS, 1990
- On the mathematical foundations of theoretical statisticsPhilosophical Transactions of the Royal Society A, 1922