The Proteasome — An Emerging Therapeutic Target in Cancer

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Abstract
This is an exciting time for cancer therapeutics. The identification of promising molecular targets has led to the development of many exciting new drugs for which an antitumor mechanism of action has been clearly delineated. Given the recent major advances in our understanding of the biology of cancer cells, one might surmise that an era of truly rational therapeutics has arrived. Nevertheless, we continue to find new therapeutic agents that target unforeseen molecular pathways.The report by Richardson et al. in this issue of the Journal (pages 2609–2617) brings to the fore a relatively new and unexpected target, the 26S . . .

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