Localization of a fibrin polymerization site complementary to Gly‐His‐Arg sequence
- 12 April 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 320 (3) , 239-242
- https://doi.org/10.1016/0014-5793(93)80594-k
Abstract
Dansyl‐labeled tetrapeptide Gly‐His‐Arg‐Pro which mimics the central fibrin polymerization site was used to investigate its binding to a number of fibrinogen fragments containing different numbers of domains. The tetrapeptide was found to bind to fragments DH(95 kDa), DL(82 kDa) and DY(63 kDa) but not to the TSD(28 kDa) fragment. The DY fragment differs from the TSD by the presence of β and βC domains. Therefore these domains, which are formed by the C‐terminal part of the β chain, possess a polymerization site complementary to the Gly‐His‐Arg containing counterpart.Keywords
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