Effects of peptides on gastric emptying

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Abstract
The effects of peptides on gastric emptying of a liquid meal were studied in rats. Gastric emptying was found to be delayed following i.p. injection of the octapeptide of cholecystokinin (CCK-8). Vasoactive intestinal peptide did not affect emptying, while substance P and neurotensin caused a moderate acceleration in gastric emptying. After oral administration of a solution containing the amino acids tryptophan and phenylalanine, but not glycine, a statistically significant inhibition of gastric emptying was observed. An involvement of CCK in the regulation of gastric emptying is suggested.