The Role of DNA damage, its Repair and its Misrepair in the Etiology of Cataract: a Review
- 1 January 1978
- journal article
- review article
- Published by S. Karger AG in Ophthalmic Research
- Vol. 10 (1) , 52-62
- https://doi.org/10.1159/000264935
Abstract
A hypothesis is presented regarding the importance of desoxyribonuclei acid (DNA) repair for maintenance of lens clarity. It is proposed that unrepaired or incorrectly repaired damage to lens epithelial cell DNA may result in decreased lens transparency either by altering normal metabolism in the epithelium or subsequently by affecting lens cell differentiation and protein synthesis in the lens cortex.Keywords
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