Glibenclamide, a Blocker of K + ATP Channels, Shows Antileishmanial Activity in Experimental Murine Cutaneous Leishmaniasis
- 1 December 2006
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 50 (12) , 4214-4216
- https://doi.org/10.1128/aac.00617-06
Abstract
Glibenclamide reduced the rate of lesion growth in BALB/c mice infected with Leishmania (Leishmania) mexicana, the effect was dose dependent, and the highest dose proved more effective than glucantime. Cross-resistance to glucantime was found in animals infected with a glibenclamide-resistant line, but combined therapy reduced lesion progression even in the glibenclamide-resistant strain.Keywords
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