Bromocriptine‐Desipramine Protocol in Treatment of Cocaine Addiction
- 1 August 1987
- journal article
- research article
- Published by Wiley in The Journal of Clinical Pharmacology
- Vol. 27 (8) , 549-554
- https://doi.org/10.1002/j.1552-4604.1987.tb03065.x
Abstract
Thirty‐six male cocaine abusers, in withdrawal, were studied for 99 days in a double‐blind design. Treatment with bromocriptine was significantly more effective than placebo in alleviating withdrawal symptoms. Adding desipramine to the bromocriptine regimen was significantly more effective than either placebo or bromocriptine alone. The authors hypothesize that these results support a model of dopamine depletion and receptor supersensitivity in cocaine withdrawal.This publication has 23 references indexed in Scilit:
- New concepts in cocaine addiction: The dopamine depletion hypothesisPublished by Elsevier ,2003
- Bromocriptine Therapy in Cocaine WithdrawalThe Journal of Clinical Pharmacology, 1987
- BROMOCRIPTINE AS TREATMENT OF COCAINE ABUSEThe Lancet, 1985
- Cocaine-induced supersensitivity of striatal dopamine receptors: role of endogenous calmodulinNeuropharmacology, 1981
- Correlation of behavioral and neurochemical effects of acute administration of cocaine in ratsLife Sciences, 1978
- Blockade of cocaine reinforcement in rats with the dopamine receptor blocker pimozide, but not with the noradrenergic blockers phentolamine or phenoxybenzamine.Canadian Journal of Psychology / Revue canadienne de psychologie, 1977
- Development of β-adrenergic receptor subsensitivity by antidepressantsNature, 1977
- On the role of ascending catecholaminergic systems in intravenous self-administration of cocainePharmacology Biochemistry and Behavior, 1977
- Self regulation of membrane receptorsNature, 1976
- Effect of Cocaine on the Disposition of Noradrenaline labelled with TritiumNature, 1960