STUDIES ON THE BIOLOGIC CHARACTERIZATION OF HUMAN GONADOTROPINS. III. COMPARISON WITH SHEEP FOLLICLESTIMULATING HORMONE*

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Abstract
The essential biologic nature of human pituitary gonadotropin as found in urine (HPG) was further investigated by comparison with sheep folliclestimulating hormone (FSH) by means of assays employing the simultaneous response of the uterus and ovajy. The parameters of these assays showed that the ovarian response to HPG was three times that to FSH, and the uterine response to HPG was two and a half times that to FSH. The dose ratios showed that HPG was twice as effective as FSH in inducing secretion of estrogen. The ovarian response to both FSH and HPG was a linear function of the log of the dose; the uterine response to HPG also was a linear function of the log of the dose but the response to FSH was not. Tt was concluded that HPG is not identical with FSH and that the widespread use in clinical literature of the term “urinary FSH” for an assay of HPG is incorrect.