Quantitative proton-decoupled 31 P MRS and 1 H MRS in the evaluation of Huntington's and Parkinson's diseases
- 1 April 1998
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 50 (4) , 1033-1040
- https://doi.org/10.1212/wnl.50.4.1033
Abstract
Objective: To determine cerebral energy status in patients with Huntington's disease(HD) and Parkinson's disease (PD). Methods: The study included 15 patients with DNA-proven, symptomatic HD and five patients with medically treated, idiopathic PD, all of whom were candidates for neurotransplant treatment, as well as 20 age-related normal subjects. Quantitative noninvasive, MRI-guided proton MRS was performed of single volumes in putamen of basal ganglia (BG), occipital gray matter, and posterior parietal white matter; in addition, quantitative phosphorus and proton-decoupled phosphorus MRS of superior biparietal white and gray matter was done. Outcome measures were quantitative metabolite ratios and millimolar concentrations of neuronal and glial markers, creatine (Cr) and adenosine triphosphate (ATP), and intracellular pH. Results: In volume-corrected control BG (10.46 ± 0.37 mM), [Cr] was 29%(p < 0.05) higher than in control gray matter (8.10 ± 1.04 mM). In HD and PD, energy metabolism was not abnormal in the four cerebral locations measured by MRS. No increase in cerebral lactate or decrease in phosphocreatine and ATP was detected. Small, systematic abnormalities in N-acetylaspartate (NAA, ddecreased), Cr (decreased), choline-containing compounds (Cho, increased), and myoinositol (mI, increased) were demonstrable in all patient's individually and in summed spectra but were insufficient to make diagnosis possible in the individual patient. Conclusion: Previously described failure of global energy metabolism in HD was not confirmed. However, quantitative 1-hydrogen MRS and decoupled 31-phosphorus MRS are sensitive to ±10% alterations in key cerebral metabolites, and may be of value in noninvasive monitoring of appropriate therapies.Keywords
This publication has 14 references indexed in Scilit:
- Observation of resolved glucose signals in 1H NMR spectra of the human brain at 4 TeslaMagnetic Resonance in Medicine, 1996
- Basic aspects of neuroimmunology as they relate to immunotherapeutic targets: Present and future prospectsAnnals of Neurology, 1995
- MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in miceJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1994
- The worldwide problem of strokeCurrent Opinion in Neurology, 1994
- A trial of disputationThe Lancet, 1994
- Message from the editorAnnals of Neurology, 1994
- Absolute Quantitation of Water and Metabolites in the Human Brain. II. Metabolite ConcentrationsJournal of Magnetic Resonance, Series B, 1993
- Improved Pulse Program for Long-Range Heteronuclear CorrelationJournal of Magnetic Resonance, Series A, 1993
- The Risk of Stroke in Patients with Acute Myocardial Infarction after Thrombolytic and Antithrombotic TreatmentNew England Journal of Medicine, 1992
- A quantitative analysis of the accuracy of In Vivo pH measurements with 31P NMR spectroscopy: Assessment of pH measurement methodologyNMR in Biomedicine, 1991