Norepinephrine and Serotonin Release upon Impact Injury to Rat Spinal Cord
- 1 January 1990
- journal article
- Published by Mary Ann Liebert Inc in Journal of Neurotrauma
- Vol. 7 (4) , 219-227
- https://doi.org/10.1089/neu.1990.7.219
Abstract
Microdialysis sampling was used to characterize the release of norepinephrine and serotonin upon impact injury to the rat spinal cord. Increases in extracellular norepinephrine concentrations in response to injury were small and of short duration. In contrast, serotonin concentrations quickly rose 35-90 times following injury and took 30-45 min to return to control levels. Bleeding caused by injury was probably the major source of the increased serotonin levels. Our results allow a role for serotonin in secondary damage upon injury to the spinal cord but suggest that norepinephrine is not a very significant contributor to such damage.Keywords
This publication has 24 references indexed in Scilit:
- Steady-state theory for quantitative microdialysis of solutes and water in vivo and in vitroLife Sciences, 1990
- Determination of Brain Interstitial Concentrations by MicrodialysisJournal of Neurochemistry, 1989
- The Role of Excitatory Amino Acids and NMDA Receptors in Traumatic Brain InjuryScience, 1989
- Effect of Impact Trauma on Neurotransmitter and Nonneurotransmitter Amino Acids in Rat Spinal CordJournal of Neurochemistry, 1989
- A potential role for excitotoxins in the pathophysiology of spinal cord injuryAnnals of Neurology, 1988
- Pharmacotherapy in Spinal Cord InjuryClinical Neuropharmacology, 1987
- Alterations in Lipid Metabolism, Na+,K+‐ATPase Activity, and Tissue Water Content of Spinal Cord Following Experimental Traumatic InjuryJournal of Neurochemistry, 1987
- Cerebral arterial spasmJournal of Neurosurgery, 1974
- Experimental vasospasm, acute and chronic, due to blood in the subarachnoid spaceJournal of Neurosurgery, 1971
- SURGERY OF EXPERIMENTAL LESION OF SPINAL CORD EQUIVALENT TO CRUSH INJURY OF FRACTURE DISLOCATION OF SPINAL COLUMNJAMA, 1911