BENIGN BREAST DISEASE .1. HORMONAL INVESTIGATION

  • 1 January 1979
    • journal article
    • research article
    • Vol. 53  (4) , 457-460
Abstract
Patients [184] with benign breast disease (BBD) were studied and compared with 50 normal women. All of the women had ovulatory cycles according to a biphasic basal body temperature and a plasma prolactin in the normal range. Their corpus luteum function was evaluated by way of plasma progesterone (P) and estradiol (E2) determinations at days 5, 7 and 9 of the hyperthermic phase. In the 184 patients, plasma P over plasma E2 ratio during the luteal phase was significantly lower than in normal women. When the patients were grouped according to type of breast lesions, it appeared that plasma P was constantly lower in all groups than in the normal women, while plasma E2 was either normal or elevated in the groups of patients with adenosis tumors and increased nodularity of both breasts. An imbalance in the secretion of E2 and P by the corpus luteum is apparently a constant finding in women with benign breast disease.

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