IN VIVO EFFECTS OF GLUCAGON ON HEPATIC GLYCOGEN, PHOSPHORYLASE AND GLUCOSE-6-PHOSPHATASE1
- 1 February 1957
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 60 (2) , 265-269
- https://doi.org/10.1210/endo-60-2-265
Abstract
RECENT studies in our laboratory on rat liver slices have revealed a critical time relationship between the addition of glucagon to the medium and the observed levels of phosphorylase activity. This study in dogs was therefore undertaken to determine in vivo the degree and duration of alterations in this enzyme and the secondary changes in hepatic glycogen content. Also measured were hepatic glucose-6-phosphatase activity, blood sugar and lactate, and serum sodium, potassium and inorganic phosphorus.Keywords
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- GLYCOGEN FRACTIONS OF LIVER AND MUSCLEJournal of Biological Chemistry, 1951