VOLATILE N-NITROSAMINES IN THE URINE OF NORMAL DONORS AND OF BLADDER-CANCER PATIENTS
- 1 January 1979
- journal article
- research article
- Vol. 39 (3) , 829-832
Abstract
Volatile N-nitrosamines were detected in the urine of male volunteers with GLC and high-pressure liquid chromatography interfaced to the thermal energy analyzer. Of 50 samples from normal males, 10 contained nitrosodimethylamine (0.02-0.10 .mu.g/l), 6 contained nitrosodiethylamine (0.02-3.10), 9 contained nitrosomorpholine (0.06-0.67), and none contained nitrosodibutylamine. Of 4 samples from bladder cancer patients, 2 contained nitrosodibutylamine (0.35 and 0.66). Cigarette smoking did not appear to be related to the pattern or amount of urinary volatile N-nitrosamines. The possibility that the N-nitrosamines arise from the diet or from endogenous production is considered.This publication has 4 references indexed in Scilit:
- Nitrite and Nitrate Are Formed by Endogenous Synthesis in the Human IntestineScience, 1978
- ASSESSMENT OF CARCINOGENIC VOLATILE N-NITROSAMINES IN TOBACCO AND IN MAINSTREAM AND SIDESTREAM SMOKE FROM CIGARETTES1977
- The effect of nitrate intake on nitrite formation in human salivaFood and Cosmetics Toxicology, 1976
- Description of the thermal energy analyzer (TEA) for trace determination of volatile and nonvolatile N-nitroso compoundsAnalytical Chemistry, 1975